2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N11845
    Sigmoidin B 87746-47-2 98%
    Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties.
    Sigmoidin B
  • HY-N11970
    Isocrenatoside 221895-09-6 98%
    Isocrenatoside (compound 6) is a cyclic octapeptide and an inhibitor of angiotensin-converting enzyme (ACE). Isocrenatoside is isolated from the ethanolic extract of Microtoena prainiana stems. Studies have found that the inhibitory efficiency of 1 mg/mL Isocrenatoside can reach 99.3%.
    Isocrenatoside
  • HY-N12007
    OAT1/3-IN-1 38393-73-6 98%
    OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage.
    OAT1/3-IN-1
  • HY-N12008
    OAT1/3-IN-2 2195434-05-8 98%
    OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage.
    OAT1/3-IN-2
  • HY-N12016
    Fulvotomentoside B 1021184-77-9 98%
    Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl4, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage.
    Fulvotomentoside B
  • HY-N12081
    Oxyresveratrol 4-O-β-D-glucopyranoside 863329-68-4 98%
    Oxyresveratrol 4-O-β-D-glucopyranoside (compound 3) is a natural product that can be obtained from the root bark of Morus atropurpurea. Oxyresveratrol 4-O-β-D-glucopyranoside has potential in studies of diabetes, arthritis, rheumatism, cough and headache.
    Oxyresveratrol 4-O-β-D-glucopyranoside
  • HY-N12092
    PSX020 2600799-45-7 98%
    PSX020 is the hosta plantaginea flower extract with antioxidant effects.
    PSX020
  • HY-N12131
    Ejaponine A 1253119-28-6 98%
    Ejaponine A (Compound 1) is an insecticidal sesquiterpene ester. Ejaponine A is obtained from the natural Euonymus japonicus. Ejaponine A has Mythimna separata killing activity (LD5089.2 μgg-1). Ejaponine A is used to kill Mythimna separata .
    Ejaponine A
  • HY-N12138
    Flaccidoside III 140400-67-5 98%
    Flaccidoside III is a triterpenoid isolated from the aerial parts of N. sativa (Ranunculaceae). Flaccidoside III inhibits α-Glucosidase (IC50: 256.7 μM) and has potential antioxidant and antidiabetic activities.
    Flaccidoside III
  • HY-N12177
    Cryptosporioptide A 1647101-05-0 98%
    Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC50 of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively.
    Cryptosporioptide A
  • HY-N12263
    3,5,6,7,8,4'-Hexamethoxyflavone 34170-18-8 99.98%
    3,5,6,7,8,4'-Hexamethoxyflavone is a inhibitor of α-Amylase with the inhibitory activity of 28.3% at 500 μM.
    3,5,6,7,8,4'-Hexamethoxyflavone
  • HY-N12292
    Acanthopanaxoside A 915792-02-8 98%
    Acanthopanaxoside A, a triterpenoid saponin, has pancreatic lipase inhibitory action.
    Acanthopanaxoside A
  • HY-N12294
    Ciwujianoside D2 114892-57-8 98%
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-N12296
    Ciwujianoside C4 114906-75-1 98%
    Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside C4
  • HY-N12313
    Corybulbine 518-77-4 98%
    Corybulbine, an alkaloid that can be isolated from the methanolic extract of Corydalis ternata, is an aldose reductase (ALR2) inhibitor. Corybulbine can be used for diabetic complications research.
    Corybulbine
  • HY-N12321
    2',3'-Dihydroxy-4',6'-dimethoxychalcone 54299-64-8 98%
    2',3'-Dihydroxy-4',6'-dimethoxychalcone (compound 1) can inhibit Amyloid β-protein (Aβ42) fibrillization and aggregation. 2',3'-Dihydroxy-4',6'-dimethoxychalcone has oral activity and can be detected in the brain.
    2',3'-Dihydroxy-4',6'-dimethoxychalcone
  • HY-N12354
    Stevisaliosides D 98%
    Stevisaliosides D (Compound 5) can be isolated from Stevia serrata roots. Stevisaliosides D inhibits PTP1B (IC50: 31.8 μM). Stevisalioside D can be used for antidiabetic research.
    Stevisaliosides D
  • HY-N12426
    Heilaohuguosu F 2763686-96-8 98%
    Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.
    Heilaohuguosu F
  • HY-N12432
    Glomeratide A 1072028-74-0 98%
    Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.
    Glomeratide A
  • HY-N12434
    Euphorblin R 2230806-06-9 98%
    Euphorblin R (EOF2) is a rhamnyl diterpenoid isolated from Euphorbia resinifera. Euphorblin R may promote lysosomal biogenesis and has the potential to be used in the study of lysosome-related diseases.
    Euphorblin R
Cat. No. Product Name / Synonyms Application Reactivity